Drug interactions
Oxcarbazepine + Trazodone
Severity: Moderate
Oxcarbazepine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine induces CYP3A4, the main enzyme that metabolizes trazodone, which may lower trazodone concentrations and weaken its effect. Oxcarbazepine can also cause hyponatremia, which adds risk since serotonergic antidepressants may do the same.
What this interaction means in plain words
Oxcarbazepine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Trazodone belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces CYP3A4, increasing trazodone clearance.
What to do
Monitor clinical response and increase the trazodone dose if necessary. Check serum sodium if symptoms of hyponatremia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Trazodone?
MediHelp rates the interaction as moderate. Oxcarbazepine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine induces CYP3A4, the main enzyme that metabolizes trazodone, which may lower trazodone concentrations and weaken its effect. Oxcarbazepine can also cause hyponatremia, which adds risk since serotonergic antidepressants may do the same.
How serious is the interaction between Oxcarbazepine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and increase the trazodone dose if necessary. Check serum sodium if symptoms of hyponatremia appear.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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