Drug interactions
Oxcarbazepine + Valbenazine
Severity: Moderate
Oxcarbazepine and Valbenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valbenazine and its active metabolite are cleared partly via CYP3A4, so inducers lower exposure and may reduce efficacy in tardive dyskinesia. Labeling advises against strong inducers; oxcarbazepine is weaker.
What this interaction means in plain words
Oxcarbazepine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Valbenazine belongs to Central Nervous System.
Why it happens
Oxcarbazepine induces CYP3A4, increasing valbenazine metabolism.
What to do
Monitor dyskinesia control and consider an alternative anticonvulsant if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Valbenazine
- Deutetrabenazine + Valbenazine Contraindicated
- Tranylcypromine + Valbenazine Contraindicated
- Amiodarone + Valbenazine Major
- Amisulpride + Valbenazine Major
- Apalutamide + Valbenazine Major
- Carbamazepine + Valbenazine Major
Frequently asked questions
Can I take Oxcarbazepine with Valbenazine?
MediHelp rates the interaction as moderate. Oxcarbazepine and Valbenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valbenazine and its active metabolite are cleared partly via CYP3A4, so inducers lower exposure and may reduce efficacy in tardive dyskinesia. Labeling advises against strong inducers; oxcarbazepine is weaker.
How serious is the interaction between Oxcarbazepine and Valbenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor dyskinesia control and consider an alternative anticonvulsant if response is lost.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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