Drug interactions
Oxcarbazepine + Vortioxetine
Severity: Moderate
Oxcarbazepine and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine is a weak-to-moderate CYP3A4 inducer and may lower vortioxetine exposure, potentially reducing antidepressant efficacy. Oxcarbazepine can also cause hyponatremia, which is additive with serotonergic antidepressants.
What this interaction means in plain words
Oxcarbazepine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxcarbazepine belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Hepatic enzyme induction by oxcarbazepine accelerates vortioxetine clearance; both drugs can cause hyponatremia.
What to do
Monitor antidepressant response and consider increasing the vortioxetine dose within the labeled maximum if efficacy falls. Check serum sodium if symptoms of hyponatremia appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Oxcarbazepine with Vortioxetine?
MediHelp rates the interaction as moderate. Oxcarbazepine and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxcarbazepine is a weak-to-moderate CYP3A4 inducer and may lower vortioxetine exposure, potentially reducing antidepressant efficacy. Oxcarbazepine can also cause hyponatremia, which is additive with serotonergic antidepressants.
How serious is the interaction between Oxcarbazepine and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and consider increasing the vortioxetine dose within the labeled maximum if efficacy falls. Check serum sodium if symptoms of hyponatremia appear.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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