Drug interactions
Oxcarbazepine + Zonisamide
Severity: Minor
Oxcarbazepine and Zonisamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zonisamide is partly metabolized by CYP3A4, so oxcarbazepine could lower its levels slightly. Clinical data showing a meaningful effect are limited.
What this interaction means in plain words
Oxcarbazepine and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxcarbazepine belongs to Central Nervous System; Zonisamide belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by oxcarbazepine may increase zonisamide clearance.
What to do
No routine adjustment is needed; monitor seizure control and consider zonisamide levels if breakthrough seizures occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Frequently asked questions
Can I take Oxcarbazepine with Zonisamide?
MediHelp rates the interaction as minor. Oxcarbazepine and Zonisamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zonisamide is partly metabolized by CYP3A4, so oxcarbazepine could lower its levels slightly. Clinical data showing a meaningful effect are limited.
How serious is the interaction between Oxcarbazepine and Zonisamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor seizure control and consider zonisamide levels if breakthrough seizures occur.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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