Drug interactions
Oxybutynin + Tiotropium-olodaterol
Severity: Moderate
Oxybutynin and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxybutynin is a strongly anticholinergic bladder antispasmodic, so it can add to tiotropium and increase dry mouth, constipation, urinary retention, blurred vision and confusion in older patients. Systemic tiotropium exposure is low, but the burden still accumulates.
What this interaction means in plain words
Oxybutynin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic effects and cognitive changes, especially in elderly patients. Consider a less anticholinergic bladder agent if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Oxybutynin
Frequently asked questions
Can I take Oxybutynin with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Oxybutynin and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxybutynin is a strongly anticholinergic bladder antispasmodic, so it can add to tiotropium and increase dry mouth, constipation, urinary retention, blurred vision and confusion in older patients. Systemic tiotropium exposure is low, but the burden still accumulates.
How serious is the interaction between Oxybutynin and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and cognitive changes, especially in elderly patients. Consider a less anticholinergic bladder agent if adverse effects appear.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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