Drug interactions
Oxybutynin + Trimipramine
Severity: Moderate
Oxybutynin and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimipramine is a tricyclic antidepressant with significant anticholinergic effects, so combined use with oxybutynin can cause additive dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
What this interaction means in plain words
Oxybutynin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxybutynin belongs to Genitourinary; Trimipramine belongs to Central Nervous System.
Why it happens
Additive muscarinic receptor antagonism.
What to do
Monitor for anticholinergic toxicity, especially in older patients and those with glaucoma or urinary obstruction. Consider an alternative to one agent if effects develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxybutynin
Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Oxybutynin with Trimipramine?
MediHelp rates the interaction as moderate. Oxybutynin and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimipramine is a tricyclic antidepressant with significant anticholinergic effects, so combined use with oxybutynin can cause additive dry mouth, constipation, urinary retention, blurred vision, tachycardia and confusion.
How serious is the interaction between Oxybutynin and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, especially in older patients and those with glaucoma or urinary obstruction. Consider an alternative to one agent if effects develop.
What other medicines interact with Oxybutynin?
MediHelp also lists interactions of Oxybutynin with, for example, Bethanechol, Clozapine, Potassium chloride. The full list is on the Oxybutynin page.
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