Drug interactions
Oxycodone + Paroxetine
Severity: Moderate
Oxycodone and Paroxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine strongly inhibits CYP2D6, which can reduce formation of oxymorphone and alter analgesia. Both drugs also have serotonergic potential, so serotonin syndrome is a concern.
What this interaction means in plain words
Oxycodone and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Paroxetine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition by paroxetine plus additive serotonergic effects.
What to do
Monitor analgesic response and titrate oxycodone to effect. Watch for serotonin syndrome signs such as tremor, agitation, hyperreflexia and fever.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Oxycodone with Paroxetine?
MediHelp rates the interaction as moderate. Oxycodone and Paroxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine strongly inhibits CYP2D6, which can reduce formation of oxymorphone and alter analgesia. Both drugs also have serotonergic potential, so serotonin syndrome is a concern.
How serious is the interaction between Oxycodone and Paroxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesic response and titrate oxycodone to effect. Watch for serotonin syndrome signs such as tremor, agitation, hyperreflexia and fever.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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