Drug interactions
Oxycodone + Rifabutin
Severity: Moderate
Oxycodone and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and can lower oxycodone concentrations, leading to reduced analgesia and possibly withdrawal symptoms in dependent patients. The induction is weaker than with rifampicin but still relevant.
What this interaction means in plain words
Oxycodone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Rifabutin belongs to Anti Bacterial.
Why it happens
Induction of CYP3A4 by rifabutin increases oxycodone clearance.
What to do
Monitor pain control and withdrawal signs and increase the oxycodone dose if needed. Reduce the dose again if rifabutin is discontinued to avoid toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Oxycodone with Rifabutin?
MediHelp rates the interaction as moderate. Oxycodone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and can lower oxycodone concentrations, leading to reduced analgesia and possibly withdrawal symptoms in dependent patients. The induction is weaker than with rifampicin but still relevant.
How serious is the interaction between Oxycodone and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor pain control and withdrawal signs and increase the oxycodone dose if needed. Reduce the dose again if rifabutin is discontinued to avoid toxicity.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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