Drug interactions
Oxycodone + Rocuronium
Severity: Moderate
Oxycodone and Rocuronium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxycodone may add to the effects of rocuronium, prolonging muscle weakness and respiratory depression. This is mainly relevant during anesthesia and intensive care.
What this interaction means in plain words
Oxycodone and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Rocuronium belongs to Musculoskeletal.
Why it happens
Additive respiratory depression from opioid central effects; a direct effect on neuromuscular transmission is not well established.
What to do
Monitor neuromuscular blockade with train-of-four testing and ensure ventilatory support. Titrate the blocker to response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxycodone and Rocuronium, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Rocuronium
Frequently asked questions
Can I take Oxycodone with Rocuronium?
MediHelp rates the interaction as moderate. Oxycodone and Rocuronium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxycodone may add to the effects of rocuronium, prolonging muscle weakness and respiratory depression. This is mainly relevant during anesthesia and intensive care.
How serious is the interaction between Oxycodone and Rocuronium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four testing and ensure ventilatory support. Titrate the blocker to response.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
