Drug interactions
Oxycodone + Selegiline
Severity: Major
Oxycodone and Selegiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline, an MAO-B inhibitor that becomes less selective at higher or transdermal doses, may cause serotonin syndrome or enhanced opioid toxicity with oxycodone. Features include hypotension, hyperthermia, agitation and CNS depression.
What this interaction means in plain words
Oxycodone and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxycodone belongs to Musculoskeletal; Selegiline belongs to Central Nervous System.
Why it happens
MAO inhibition combined with opioid serotonergic and CNS depressant effects.
What to do
Avoid concurrent use where possible, particularly with transdermal selegiline. If unavoidable, use the lowest oxycodone dose and monitor for serotonin toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Oxycodone with Selegiline?
MediHelp rates the interaction as major. Oxycodone and Selegiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Selegiline, an MAO-B inhibitor that becomes less selective at higher or transdermal doses, may cause serotonin syndrome or enhanced opioid toxicity with oxycodone. Features include hypotension, hyperthermia, agitation and CNS depression.
How serious is the interaction between Oxycodone and Selegiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible, particularly with transdermal selegiline. If unavoidable, use the lowest oxycodone dose and monitor for serotonin toxicity.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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