Drug interactions
Oxycodone + Suvorexant
Severity: Moderate
Oxycodone and Suvorexant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Suvorexant, an orexin antagonist hypnotic, adds to opioid sedation and may impair next-day alertness and respiratory drive. Combined CNS depression can lead to hypotension and respiratory compromise.
What this interaction means in plain words
Oxycodone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxycodone belongs to Musculoskeletal; Suvorexant belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism and opioid agonism.
What to do
Use the lowest effective dose of each drug and counsel about next-day impairment. Monitor for excess sedation and respiratory depression, especially in older or COPD patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Suvorexant
Frequently asked questions
Can I take Oxycodone with Suvorexant?
MediHelp rates the interaction as moderate. Oxycodone and Suvorexant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Suvorexant, an orexin antagonist hypnotic, adds to opioid sedation and may impair next-day alertness and respiratory drive. Combined CNS depression can lead to hypotension and respiratory compromise.
How serious is the interaction between Oxycodone and Suvorexant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective dose of each drug and counsel about next-day impairment. Monitor for excess sedation and respiratory depression, especially in older or COPD patients.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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