Drug interactions
Oxymorphone + Paliperidone
Severity: Moderate
Oxymorphone and Paliperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can cause somnolence and orthostatic hypotension, adding to the sedative and respiratory depressant effects of oxymorphone. The effect is mainly pharmacodynamic and dose related.
What this interaction means in plain words
Oxymorphone and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Paliperidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotension.
What to do
Use low starting doses and monitor sedation, blood pressure and respiratory status. Counsel patients on dizziness and driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Oxymorphone with Paliperidone?
MediHelp rates the interaction as moderate. Oxymorphone and Paliperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can cause somnolence and orthostatic hypotension, adding to the sedative and respiratory depressant effects of oxymorphone. The effect is mainly pharmacodynamic and dose related.
How serious is the interaction between Oxymorphone and Paliperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use low starting doses and monitor sedation, blood pressure and respiratory status. Counsel patients on dizziness and driving.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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