Drug interactions
Oxymorphone + Perphenazine
Severity: Moderate
Oxymorphone and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine is a phenothiazine with sedative properties and adds to opioid-induced CNS and respiratory depression, with possible hypotension. Its CYP2D6 inhibition has little relevance for oxymorphone, which is mainly cleared by glucuronidation, so the sedative effect dominates.
What this interaction means in plain words
Oxymorphone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Perphenazine belongs to Central Nervous System.
Why it happens
Additive CNS depression and hypotensive effects of the antipsychotic and the opioid.
What to do
Start with lower doses of oxymorphone and titrate while monitoring sedation, respiratory rate and blood pressure. Avoid additional CNS depressants where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Oxymorphone with Perphenazine?
MediHelp rates the interaction as moderate. Oxymorphone and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine is a phenothiazine with sedative properties and adds to opioid-induced CNS and respiratory depression, with possible hypotension. Its CYP2D6 inhibition has little relevance for oxymorphone, which is mainly cleared by glucuronidation, so the sedative effect dominates.
How serious is the interaction between Oxymorphone and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start with lower doses of oxymorphone and titrate while monitoring sedation, respiratory rate and blood pressure. Avoid additional CNS depressants where possible.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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