Drug interactions
Oxymorphone + Selinexor
Severity: Moderate
Oxymorphone and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological adverse effects, and oxymorphone adds sedation and cognitive impairment. Together they may increase the risk of falls, injury and excessive CNS depression.
What this interaction means in plain words
Oxymorphone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Selinexor belongs to Oncology.
Why it happens
Additive pharmacodynamic CNS effects; no pharmacokinetic mechanism is established.
What to do
Assess neurological status and sedation at treatment start and after dose changes, and start oxymorphone at the lowest effective dose. Counsel patients on fall risk and avoid driving, and reduce or stop the opioid if confusion or marked sedation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Oxymorphone with Selinexor?
MediHelp rates the interaction as moderate. Oxymorphone and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological adverse effects, and oxymorphone adds sedation and cognitive impairment. Together they may increase the risk of falls, injury and excessive CNS depression.
How serious is the interaction between Oxymorphone and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Assess neurological status and sedation at treatment start and after dose changes, and start oxymorphone at the lowest effective dose. Counsel patients on fall risk and avoid driving, and reduce or stop the opioid if confusion or marked sedation develops.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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