Drug interactions
Oxymorphone + Tipranavir
Severity: Minor
Oxymorphone and Tipranavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxymorphone is cleared mainly by glucuronidation, not CYP2D6 or CYP3A4, so a meaningful pharmacokinetic interaction with ritonavir-boosted tipranavir is unlikely. Tipranavir may affect UGT activity, but this is not clinically established.
What this interaction means in plain words
Oxymorphone and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oxymorphone belongs to Musculoskeletal; Tipranavir belongs to Anti Virals.
Why it happens
Theoretical metabolic effect; no established mechanism, since oxymorphone does not rely on CYP2D6.
What to do
No empirical dose adjustment is needed; monitor analgesic response and sedation when the antiretroviral is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Oxymorphone with Tipranavir?
MediHelp rates the interaction as minor. Oxymorphone and Tipranavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxymorphone is cleared mainly by glucuronidation, not CYP2D6 or CYP3A4, so a meaningful pharmacokinetic interaction with ritonavir-boosted tipranavir is unlikely. Tipranavir may affect UGT activity, but this is not clinically established.
How serious is the interaction between Oxymorphone and Tipranavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose adjustment is needed; monitor analgesic response and sedation when the antiretroviral is started or stopped.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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