Drug interactions
Oxymorphone + Ziconotide
Severity: Moderate
Oxymorphone and Ziconotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause CNS depression, and ziconotide additionally carries risk of confusion, somnolence and reduced consciousness. Combined use may increase sedation, although intrathecal ziconotide is not expected to interact pharmacokinetically with opioids.
What this interaction means in plain words
Oxymorphone and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxymorphone belongs to Musculoskeletal; Ziconotide belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor level of consciousness and cognitive status, particularly after dose changes. Reduce the opioid dose if excessive sedation occurs, and stop ziconotide if there is persistent cognitive impairment or reduced consciousness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Ziconotide
- Clozapine + Ziconotide Major
- Alprazolam + Ziconotide Moderate
- Amitriptyline + Ziconotide Moderate
- Amobarbital + Ziconotide Moderate
- Aripiprazole + Ziconotide Moderate
- Armodafinil + Ziconotide Moderate
Frequently asked questions
Can I take Oxymorphone with Ziconotide?
MediHelp rates the interaction as moderate. Oxymorphone and Ziconotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause CNS depression, and ziconotide additionally carries risk of confusion, somnolence and reduced consciousness. Combined use may increase sedation, although intrathecal ziconotide is not expected to interact pharmacokinetically with opioids.
How serious is the interaction between Oxymorphone and Ziconotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor level of consciousness and cognitive status, particularly after dose changes. Reduce the opioid dose if excessive sedation occurs, and stop ziconotide if there is persistent cognitive impairment or reduced consciousness.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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