Drug interactions
Ozanimod + Pantoprazole
Severity: Moderate
Ozanimod and Pantoprazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pantoprazole can inhibit the efflux transporter BCRP in the gut. Ozanimod's active metabolites are BCRP substrates, so exposure could increase and raise the risk of adverse effects. The clinical significance with pantoprazole is uncertain.
What this interaction means in plain words
Ozanimod and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Pantoprazole belongs to Gastrointestinal Tract.
Why it happens
Inhibition of BCRP by pantoprazole may increase exposure to ozanimod active metabolites.
What to do
Monitor heart rate, blood pressure and liver tests, and watch for ozanimod adverse effects. Consider an alternative acid suppressant if problems arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pantoprazole
- Pantoprazole + Rilpivirine Contraindicated
- Acalabrutinib + Pantoprazole Major
- Atazanavir + Pantoprazole Major
- Dacomitinib + Pantoprazole Major
- Dasatinib + Pantoprazole Major
- Erlotinib + Pantoprazole Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Pantoprazole?
MediHelp rates the interaction as moderate. Ozanimod and Pantoprazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pantoprazole can inhibit the efflux transporter BCRP in the gut. Ozanimod's active metabolites are BCRP substrates, so exposure could increase and raise the risk of adverse effects. The clinical significance with pantoprazole is uncertain.
How serious is the interaction between Ozanimod and Pantoprazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and liver tests, and watch for ozanimod adverse effects. Consider an alternative acid suppressant if problems arise.
What other medicines interact with Pantoprazole?
MediHelp also lists interactions of Pantoprazole with, for example, Rilpivirine, Acalabrutinib, Atazanavir. The full list is on the Pantoprazole page.
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