Drug interactions
Ozanimod + Paroxetine
Severity: Major
Ozanimod and Paroxetine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's metabolite inhibits MAO-B in vitro, and combining it with serotonergic drugs like paroxetine may cause serotonin syndrome or hypertensive reactions. The clinical risk is uncertain but labeling advises caution.
What this interaction means in plain words
Ozanimod and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Paroxetine belongs to Central Nervous System.
Why it happens
Possible MAO-B inhibition by an ozanimod metabolite plus serotonin reuptake inhibition by paroxetine.
What to do
Avoid if possible, or monitor blood pressure and for serotonin toxicity. Allow adequate washout of paroxetine when switching.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Paroxetine?
MediHelp rates the interaction as major. Ozanimod and Paroxetine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's metabolite inhibits MAO-B in vitro, and combining it with serotonergic drugs like paroxetine may cause serotonin syndrome or hypertensive reactions. The clinical risk is uncertain but labeling advises caution.
How serious is the interaction between Ozanimod and Paroxetine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible, or monitor blood pressure and for serotonin toxicity. Allow adequate washout of paroxetine when switching.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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