Drug interactions
Ozanimod + Pazopanib
Severity: Moderate
Ozanimod and Pazopanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib prolongs QT and ozanimod can slow heart rate, which together may increase the risk of bradycardia-related arrhythmia. Ozanimod is generally not started in patients on QT-prolonging drugs with arrhythmogenic potential.
What this interaction means in plain words
Ozanimod and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Pazopanib belongs to Oncology.
Why it happens
Additive effects of QT prolongation and S1P-receptor-mediated heart rate slowing.
What to do
Obtain an ECG before starting ozanimod and seek cardiology advice. Monitor heart rate and QTc during initiation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Pazopanib?
MediHelp rates the interaction as moderate. Ozanimod and Pazopanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib prolongs QT and ozanimod can slow heart rate, which together may increase the risk of bradycardia-related arrhythmia. Ozanimod is generally not started in patients on QT-prolonging drugs with arrhythmogenic potential.
How serious is the interaction between Ozanimod and Pazopanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and seek cardiology advice. Monitor heart rate and QTc during initiation.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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