Drug interactions
Ozanimod + Pimavanserin
Severity: Moderate
Ozanimod and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin can prolong the QT interval and ozanimod may slow heart rate at initiation. Combined use may increase the risk of arrhythmia, particularly torsades de pointes.
What this interaction means in plain words
Ozanimod and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive effects of QT prolongation with ozanimod-related bradycardia.
What to do
Obtain a baseline ECG and seek cardiology advice before starting ozanimod in a patient taking pimavanserin. Monitor heart rate and QTc, and correct electrolytes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Pimavanserin?
MediHelp rates the interaction as moderate. Ozanimod and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pimavanserin can prolong the QT interval and ozanimod may slow heart rate at initiation. Combined use may increase the risk of arrhythmia, particularly torsades de pointes.
How serious is the interaction between Ozanimod and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and seek cardiology advice before starting ozanimod in a patient taking pimavanserin. Monitor heart rate and QTc, and correct electrolytes.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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