Drug interactions
Ozanimod + Pseudoephedrine
Severity: Major
Ozanimod and Pseudoephedrine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ozanimod's active metabolites inhibit MAO-B in vitro, and labeling warns about hypertensive crisis with drugs that increase norepinephrine. Pseudoephedrine releases norepinephrine and can raise blood pressure on its own. Severe MAO inhibitor-type reactions have been seen with non-selective MAOIs, though the risk with ozanimod is less certain.
What this interaction means in plain words
Ozanimod and Pseudoephedrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ozanimod belongs to Central Nervous System; Pseudoephedrine belongs to Respiratory.
Why it happens
MAO-B inhibition by ozanimod metabolites may potentiate norepinephrine release caused by pseudoephedrine.
What to do
Avoid pseudoephedrine during ozanimod therapy and use a non-sympathomimetic decongestant. If unavoidable, monitor blood pressure closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Pseudoephedrine?
MediHelp rates the interaction as major. Ozanimod and Pseudoephedrine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ozanimod's active metabolites inhibit MAO-B in vitro, and labeling warns about hypertensive crisis with drugs that increase norepinephrine. Pseudoephedrine releases norepinephrine and can raise blood pressure on its own. Severe MAO inhibitor-type reactions have been seen with non-selective MAOIs, though the risk with ozanimod is less certain.
How serious is the interaction between Ozanimod and Pseudoephedrine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid pseudoephedrine during ozanimod therapy and use a non-sympathomimetic decongestant. If unavoidable, monitor blood pressure closely.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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