Drug interactions
Ozanimod + Quinine
Severity: Moderate
Ozanimod and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both quinine and ozanimod can affect cardiac conduction, with quinine prolonging the QT interval and ozanimod slowing heart rate. Together they may increase the risk of bradycardia-related arrhythmia such as torsades de pointes.
What this interaction means in plain words
Ozanimod and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Quinine belongs to Anti Parasitic.
Why it happens
Additive effects on cardiac conduction: QT prolongation by quinine and heart rate slowing by ozanimod.
What to do
Obtain an ECG before starting ozanimod in patients taking quinine, and seek cardiology advice if the QTc is prolonged. Monitor heart rate and ECG during co-administration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Quinine?
MediHelp rates the interaction as moderate. Ozanimod and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both quinine and ozanimod can affect cardiac conduction, with quinine prolonging the QT interval and ozanimod slowing heart rate. Together they may increase the risk of bradycardia-related arrhythmia such as torsades de pointes.
How serious is the interaction between Ozanimod and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod in patients taking quinine, and seek cardiology advice if the QTc is prolonged. Monitor heart rate and ECG during co-administration.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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