Drug interactions
Ozanimod + Sorafenib
Severity: Moderate
Ozanimod and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval and ozanimod can slow heart rate. Slowing of heart rate in a patient with QT prolongation can increase the risk of torsades de pointes.
What this interaction means in plain words
Ozanimod and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive QT prolongation from sorafenib combined with ozanimod-related bradycardia.
What to do
Obtain an ECG before starting ozanimod and monitor heart rate and QTc during co-therapy. Seek cardiology advice if baseline QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Sorafenib?
MediHelp rates the interaction as moderate. Ozanimod and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval and ozanimod can slow heart rate. Slowing of heart rate in a patient with QT prolongation can increase the risk of torsades de pointes.
How serious is the interaction between Ozanimod and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting ozanimod and monitor heart rate and QTc during co-therapy. Seek cardiology advice if baseline QTc is prolonged.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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