Drug interactions
Ozanimod + Sunitinib
Severity: Moderate
Ozanimod and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib may inhibit BCRP, the transporter involved in the disposition of ozanimod's active metabolites. Higher metabolite exposure could increase ozanimod adverse effects such as bradycardia, hepatic enzyme elevation and infection risk.
What this interaction means in plain words
Ozanimod and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ozanimod belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
Possible BCRP inhibition by sunitinib raises exposure to ozanimod's active metabolites.
What to do
Monitor heart rate, liver enzymes and signs of infection when the two are combined. Consider an alternative if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Ozanimod
- Isocarboxazid + Ozanimod Contraindicated
- Linezolid + Ozanimod Contraindicated
- Ozanimod + Phenelzine Contraindicated
- Ozanimod + Procarbazine Contraindicated
- Ozanimod + Rasagiline Contraindicated
- Ozanimod + Safinamide Contraindicated
Frequently asked questions
Can I take Ozanimod with Sunitinib?
MediHelp rates the interaction as moderate. Ozanimod and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib may inhibit BCRP, the transporter involved in the disposition of ozanimod's active metabolites. Higher metabolite exposure could increase ozanimod adverse effects such as bradycardia, hepatic enzyme elevation and infection risk.
How serious is the interaction between Ozanimod and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, liver enzymes and signs of infection when the two are combined. Consider an alternative if adverse effects emerge.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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