Drug interactions
Paclitaxel + Pravastatin
Severity: Minor
Paclitaxel and Pravastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel may inhibit hepatic uptake of pravastatin in vitro, but a clinically relevant increase in statin toxicity has not been established.
What this interaction means in plain words
Paclitaxel and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Pravastatin belongs to Cardiovascular.
Why it happens
Possible OATP1B1 inhibition by paclitaxel.
What to do
No dose change is needed. Monitor for myalgia during chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pravastatin
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Pravastatin?
MediHelp rates the interaction as minor. Paclitaxel and Pravastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel may inhibit hepatic uptake of pravastatin in vitro, but a clinically relevant increase in statin toxicity has not been established.
How serious is the interaction between Paclitaxel and Pravastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for myalgia during chemotherapy.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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