Drug interactions
Paclitaxel + Ribociclib
Severity: Moderate
Paclitaxel and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ribociclib inhibits CYP3A4, a secondary route of paclitaxel metabolism, so paclitaxel exposure may increase. Both cause neutropenia, so hematologic toxicity may be additive.
What this interaction means in plain words
Paclitaxel and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Ribociclib belongs to Oncology.
Why it happens
CYP3A4 inhibition by ribociclib reduces paclitaxel metabolism, with additive myelosuppression.
What to do
Monitor neutrophil counts frequently and adjust paclitaxel dose if neutropenia is severe.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Paclitaxel with Ribociclib?
MediHelp rates the interaction as moderate. Paclitaxel and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ribociclib inhibits CYP3A4, a secondary route of paclitaxel metabolism, so paclitaxel exposure may increase. Both cause neutropenia, so hematologic toxicity may be additive.
How serious is the interaction between Paclitaxel and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts frequently and adjust paclitaxel dose if neutropenia is severe.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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