Drug interactions
Paclitaxel + Rosiglitazone
Severity: Minor
Paclitaxel and Rosiglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel is partly cleared by CYP2C8, and rosiglitazone is a substrate and weak inhibitor of this enzyme. A clinically significant rise in paclitaxel exposure has not been established.
What this interaction means in plain words
Paclitaxel and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Rosiglitazone belongs to Endocrine.
Why it happens
Possible weak CYP2C8 competition or inhibition reducing paclitaxel clearance.
What to do
No dose change is needed. Monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosiglitazone
- Insulin aspart protamine / insulin aspart + Rosiglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Insulin aspart + Rosiglitazone Major
- Insulin degludec / insulin aspart + Rosiglitazone Major
- Insulin degludec-insulin aspart + Rosiglitazone Major
- Insulin degludec-liraglutide + Rosiglitazone Major
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Rosiglitazone?
MediHelp rates the interaction as minor. Paclitaxel and Rosiglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel is partly cleared by CYP2C8, and rosiglitazone is a substrate and weak inhibitor of this enzyme. A clinically significant rise in paclitaxel exposure has not been established.
How serious is the interaction between Paclitaxel and Rosiglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for paclitaxel toxicity such as neutropenia and neuropathy.
What other medicines interact with Rosiglitazone?
MediHelp also lists interactions of Rosiglitazone with, for example, Insulin aspart protamine / insulin aspart, Insulin aspart-insulin aspart protamine, Insulin aspart. The full list is on the Rosiglitazone page.
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