Drug interactions
Paclitaxel + Rosuvastatin
Severity: Minor
Paclitaxel and Rosuvastatin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel can inhibit OATP1B1 in vitro, which could in theory raise rosuvastatin levels. A clinically significant effect has not been shown.
What this interaction means in plain words
Paclitaxel and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
Why it happens
Possible inhibition of OATP1B1-mediated hepatic uptake of rosuvastatin; clinical relevance is unproven.
What to do
No dose change is needed. Watch for muscle symptoms during chemotherapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rosuvastatin
Other interactions of Paclitaxel
Frequently asked questions
Can I take Paclitaxel with Rosuvastatin?
MediHelp rates the interaction as minor. Paclitaxel and Rosuvastatin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Paclitaxel can inhibit OATP1B1 in vitro, which could in theory raise rosuvastatin levels. A clinically significant effect has not been shown.
How serious is the interaction between Paclitaxel and Rosuvastatin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Watch for muscle symptoms during chemotherapy.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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