Drug interactions
Paclitaxel + Sirolimus
Severity: Minor
Paclitaxel and Sirolimus: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sirolimus may inhibit P-glycoprotein and could modestly raise paclitaxel levels. Clinical evidence is limited, and myelosuppression is the main concern.
What this interaction means in plain words
Paclitaxel and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Possible P-glycoprotein inhibition by sirolimus reduces paclitaxel efflux.
What to do
Monitor blood counts during combined therapy; no preemptive dose change is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Frequently asked questions
Can I take Paclitaxel with Sirolimus?
MediHelp rates the interaction as minor. Paclitaxel and Sirolimus have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sirolimus may inhibit P-glycoprotein and could modestly raise paclitaxel levels. Clinical evidence is limited, and myelosuppression is the main concern.
How serious is the interaction between Paclitaxel and Sirolimus?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts during combined therapy; no preemptive dose change is needed.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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