Drug interactions
Paclitaxel + Tacrolimus
Severity: Moderate
Paclitaxel and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tacrolimus inhibits P-glycoprotein and may increase paclitaxel exposure. Both can be toxic, so enhanced myelosuppression or neuropathy is possible, and paclitaxel vehicle effects on tacrolimus handling have been reported.
What this interaction means in plain words
Paclitaxel and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
P-glycoprotein inhibition by tacrolimus reduces paclitaxel efflux; both are CYP3A4 substrates.
What to do
Monitor blood counts, neurotoxicity and tacrolimus trough levels, and adjust doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Frequently asked questions
Can I take Paclitaxel with Tacrolimus?
MediHelp rates the interaction as moderate. Paclitaxel and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tacrolimus inhibits P-glycoprotein and may increase paclitaxel exposure. Both can be toxic, so enhanced myelosuppression or neuropathy is possible, and paclitaxel vehicle effects on tacrolimus handling have been reported.
How serious is the interaction between Paclitaxel and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, neurotoxicity and tacrolimus trough levels, and adjust doses as needed.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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