Drug interactions
Paclitaxel + Tecovirimat
Severity: Minor
Paclitaxel and Tecovirimat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tecovirimat is a weak CYP2C8 inhibitor and a weak CYP3A4 inducer, so effects on paclitaxel could go in either direction. The net effect is probably small.
What this interaction means in plain words
Paclitaxel and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paclitaxel belongs to Oncology; Tecovirimat belongs to Miscellaneous.
Why it happens
Weak CYP2C8 inhibition may raise paclitaxel levels while weak CYP3A4 induction may lower them.
What to do
No empirical adjustment is needed. Monitor for paclitaxel toxicity and for reduced efficacy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paclitaxel
Other interactions of Tecovirimat
- Bosentan + Tecovirimat Moderate
- Cyclosporin + Tecovirimat Moderate
- Darunavir + Tecovirimat Moderate
- Ethinyl estradiol-drospirenone + Tecovirimat Moderate
- Ethinyl estradiol-levonorgestrel + Tecovirimat Moderate
- Glimepiride-pioglitazone + Tecovirimat Moderate
Frequently asked questions
Can I take Paclitaxel with Tecovirimat?
MediHelp rates the interaction as minor. Paclitaxel and Tecovirimat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tecovirimat is a weak CYP2C8 inhibitor and a weak CYP3A4 inducer, so effects on paclitaxel could go in either direction. The net effect is probably small.
How serious is the interaction between Paclitaxel and Tecovirimat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical adjustment is needed. Monitor for paclitaxel toxicity and for reduced efficacy.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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