Drug interactions
Paclitaxel + Tipranavir
Severity: Major
Paclitaxel and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir, given with ritonavir, can raise paclitaxel concentrations. This increases the risk of neutropenia and neuropathy.
What this interaction means in plain words
Paclitaxel and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Paclitaxel belongs to Oncology; Tipranavir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 and P-glycoprotein (largely from the ritonavir booster) reduces paclitaxel clearance.
What to do
Choose an alternative antiretroviral if possible. If it is unavoidable, monitor blood counts and neuropathy and reduce the paclitaxel dose if toxicity appears.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paclitaxel
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Paclitaxel with Tipranavir?
MediHelp rates the interaction as major. Paclitaxel and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir, given with ritonavir, can raise paclitaxel concentrations. This increases the risk of neutropenia and neuropathy.
How serious is the interaction between Paclitaxel and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose an alternative antiretroviral if possible. If it is unavoidable, monitor blood counts and neuropathy and reduce the paclitaxel dose if toxicity appears.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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