Drug interactions
Paclitaxel + Trastuzumab deruxtecan
Severity: Moderate
Paclitaxel and Trastuzumab deruxtecan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause myelosuppression, so neutropenia and infection risk may increase when they are combined. Paclitaxel may also modestly raise trastuzumab exposure.
What this interaction means in plain words
Paclitaxel and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Trastuzumab deruxtecan belongs to Oncology.
Why it happens
Additive myelosuppressive effects; the pharmacokinetic effect on trastuzumab is unexplained.
What to do
Monitor neutrophil counts and signs of infection. Delay or reduce doses for grade 3 or higher neutropenia according to the labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Trastuzumab deruxtecan
Frequently asked questions
Can I take Paclitaxel with Trastuzumab deruxtecan?
MediHelp rates the interaction as moderate. Paclitaxel and Trastuzumab deruxtecan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause myelosuppression, so neutropenia and infection risk may increase when they are combined. Paclitaxel may also modestly raise trastuzumab exposure.
How serious is the interaction between Paclitaxel and Trastuzumab deruxtecan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neutrophil counts and signs of infection. Delay or reduce doses for grade 3 or higher neutropenia according to the labeling.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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