Drug interactions
Paclitaxel + Trimethoprim
Severity: Moderate
Paclitaxel and Trimethoprim: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trimethoprim inhibits CYP2C8 weakly to moderately and may raise paclitaxel exposure. Added bone marrow suppression from trimethoprim may also add to hematologic toxicity.
What this interaction means in plain words
Paclitaxel and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Trimethoprim belongs to Anti Bacterial.
Why it happens
Inhibition of CYP2C8-mediated paclitaxel metabolism.
What to do
Monitor blood counts and neuropathy during co-use. Consider an alternative antibiotic if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Trimethoprim
Frequently asked questions
Can I take Paclitaxel with Trimethoprim?
MediHelp rates the interaction as moderate. Paclitaxel and Trimethoprim can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trimethoprim inhibits CYP2C8 weakly to moderately and may raise paclitaxel exposure. Added bone marrow suppression from trimethoprim may also add to hematologic toxicity.
How serious is the interaction between Paclitaxel and Trimethoprim?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy during co-use. Consider an alternative antibiotic if toxicity develops.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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