Drug interactions
Paclitaxel + Trofinetide
Severity: Moderate
Paclitaxel and Trofinetide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trofinetide inhibits OATP1B1 and OATP1B3 in vitro, and paclitaxel is an OATP1B3 substrate. Reduced hepatic uptake could raise paclitaxel concentrations, although clinical data are lacking.
What this interaction means in plain words
Paclitaxel and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Trofinetide belongs to Central Nervous System.
Why it happens
Inhibition of hepatic OATP1B1/1B3 uptake may reduce paclitaxel hepatic clearance.
What to do
Monitor for paclitaxel toxicity such as neutropenia and neuropathy if co-administered. Consider paclitaxel dose reduction if adverse effects increase.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Trofinetide
Frequently asked questions
Can I take Paclitaxel with Trofinetide?
MediHelp rates the interaction as moderate. Paclitaxel and Trofinetide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trofinetide inhibits OATP1B1 and OATP1B3 in vitro, and paclitaxel is an OATP1B3 substrate. Reduced hepatic uptake could raise paclitaxel concentrations, although clinical data are lacking.
How serious is the interaction between Paclitaxel and Trofinetide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paclitaxel toxicity such as neutropenia and neuropathy if co-administered. Consider paclitaxel dose reduction if adverse effects increase.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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