Drug interactions
Paclitaxel + Vemurafenib
Severity: Moderate
Paclitaxel and Vemurafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vemurafenib inhibits P-glycoprotein and may increase paclitaxel exposure. Toxicity such as neutropenia or neuropathy could be greater.
What this interaction means in plain words
Paclitaxel and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paclitaxel belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux of paclitaxel.
What to do
Monitor blood counts and neuropathy. Reduce the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Vemurafenib
Frequently asked questions
Can I take Paclitaxel with Vemurafenib?
MediHelp rates the interaction as moderate. Paclitaxel and Vemurafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vemurafenib inhibits P-glycoprotein and may increase paclitaxel exposure. Toxicity such as neutropenia or neuropathy could be greater.
How serious is the interaction between Paclitaxel and Vemurafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy. Reduce the paclitaxel dose if toxicity develops.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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