Drug interactions
Paclitaxel protein bound + Posaconazole
Severity: Moderate
Paclitaxel protein bound and Posaconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may raise paclitaxel exposure because paclitaxel is metabolized by CYP3A4 and CYP2C8. This could increase neutropenia and neuropathy.
What this interaction means in plain words
Paclitaxel protein bound and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated metabolism of paclitaxel.
What to do
Monitor blood counts and neuropathy and consider paclitaxel dose reduction if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Paclitaxel protein bound with Posaconazole?
MediHelp rates the interaction as moderate. Paclitaxel protein bound and Posaconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Posaconazole may raise paclitaxel exposure because paclitaxel is metabolized by CYP3A4 and CYP2C8. This could increase neutropenia and neuropathy.
How serious is the interaction between Paclitaxel protein bound and Posaconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy and consider paclitaxel dose reduction if toxicity develops.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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