Drug interactions
Paclitaxel protein bound + Teriflunomide
Severity: Moderate
Paclitaxel protein bound and Teriflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Teriflunomide weakly inhibits CYP2C8, which contributes to paclitaxel metabolism. Paclitaxel exposure may rise, potentially increasing myelosuppression and neuropathy.
What this interaction means in plain words
Paclitaxel protein bound and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C8-mediated paclitaxel metabolism by teriflunomide.
What to do
Monitor blood counts and neuropathy symptoms, and reduce the paclitaxel dose if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Teriflunomide
Frequently asked questions
Can I take Paclitaxel protein bound with Teriflunomide?
MediHelp rates the interaction as moderate. Paclitaxel protein bound and Teriflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Teriflunomide weakly inhibits CYP2C8, which contributes to paclitaxel metabolism. Paclitaxel exposure may rise, potentially increasing myelosuppression and neuropathy.
How serious is the interaction between Paclitaxel protein bound and Teriflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms, and reduce the paclitaxel dose if toxicity develops.
What other medicines interact with Teriflunomide?
MediHelp also lists interactions of Teriflunomide with, for example, Ifosfamide, Lomustine, Amiodarone. The full list is on the Teriflunomide page.
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