Drug interactions
Pacritinib + Pimozide
Severity: Major
Pacritinib and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib can inhibit CYP3A4 and may increase pimozide concentrations. Higher pimozide exposure increases the risk of QT prolongation and torsades de pointes.
What this interaction means in plain words
Pacritinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pacritinib belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated pimozide metabolism by pacritinib.
What to do
Avoid the combination and use an alternative to pimozide. If it is unavoidable, monitor ECG and use the lowest effective pimozide dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Pimozide?
MediHelp rates the interaction as major. Pacritinib and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pacritinib can inhibit CYP3A4 and may increase pimozide concentrations. Higher pimozide exposure increases the risk of QT prolongation and torsades de pointes.
How serious is the interaction between Pacritinib and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an alternative to pimozide. If it is unavoidable, monitor ECG and use the lowest effective pimozide dose.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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