Drug interactions
Pacritinib + Theophylline
Severity: Moderate
Pacritinib and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib may inhibit CYP1A2, the main enzyme clearing theophylline. Theophylline levels may therefore rise, with a risk of nausea, tachycardia, arrhythmias and seizures.
What this interaction means in plain words
Pacritinib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pacritinib belongs to Oncology; Theophylline belongs to Respiratory.
Why it happens
Pacritinib inhibits CYP1A2, reducing hepatic clearance of theophylline.
What to do
Monitor theophylline serum levels and clinical signs of toxicity, and reduce the theophylline dose if levels climb.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Theophylline?
MediHelp rates the interaction as moderate. Pacritinib and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pacritinib may inhibit CYP1A2, the main enzyme clearing theophylline. Theophylline levels may therefore rise, with a risk of nausea, tachycardia, arrhythmias and seizures.
How serious is the interaction between Pacritinib and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels and clinical signs of toxicity, and reduce the theophylline dose if levels climb.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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