Drug interactions
Pacritinib + Topiramate
Severity: Minor
Pacritinib and Topiramate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pacritinib is metabolized by CYP3A4, and topiramate is only a weak inducer, so any reduction in pacritinib exposure is likely small. The significance is uncertain and not well characterized.
What this interaction means in plain words
Pacritinib and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pacritinib belongs to Oncology; Topiramate belongs to Central Nervous System.
Why it happens
Weak CYP3A4 induction by topiramate may modestly reduce pacritinib exposure.
What to do
No routine dose adjustment is needed. Monitor response to pacritinib, including spleen size and symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Topiramate
Other interactions of Pacritinib
- Clarithromycin + Pacritinib Contraindicated
- Ketoconazole + Pacritinib Contraindicated
- Pacritinib + Posaconazole Contraindicated
- Pacritinib + Voriconazole Contraindicated
- Amiodarone + Pacritinib Major
- Carbamazepine + Pacritinib Major
Frequently asked questions
Can I take Pacritinib with Topiramate?
MediHelp rates the interaction as minor. Pacritinib and Topiramate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pacritinib is metabolized by CYP3A4, and topiramate is only a weak inducer, so any reduction in pacritinib exposure is likely small. The significance is uncertain and not well characterized.
How serious is the interaction between Pacritinib and Topiramate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose adjustment is needed. Monitor response to pacritinib, including spleen size and symptoms.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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