Drug interactions
Palbociclib + Quinine
Severity: Moderate
Palbociclib and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palbociclib is a weak time-dependent CYP3A4 inhibitor and may modestly raise quinine concentrations. Because quinine has a narrow therapeutic window with risks of QT prolongation and cinchonism, higher exposure could matter.
What this interaction means in plain words
Palbociclib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palbociclib belongs to Oncology; Quinine belongs to Anti Parasitic.
Why it happens
Palbociclib inhibition of CYP3A4-mediated quinine metabolism.
What to do
Monitor for quinine toxicity such as tinnitus, hypoglycemia and QTc prolongation, and obtain an ECG if risk factors exist. Reduce the quinine dose if signs of toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Palbociclib and Quinine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Palbociclib
Frequently asked questions
Can I take Palbociclib with Quinine?
MediHelp rates the interaction as moderate. Palbociclib and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palbociclib is a weak time-dependent CYP3A4 inhibitor and may modestly raise quinine concentrations. Because quinine has a narrow therapeutic window with risks of QT prolongation and cinchonism, higher exposure could matter.
How serious is the interaction between Palbociclib and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for quinine toxicity such as tinnitus, hypoglycemia and QTc prolongation, and obtain an ECG if risk factors exist. Reduce the quinine dose if signs of toxicity appear.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
