Drug interactions
Palbociclib + Trastuzumab
Severity: Moderate
Palbociclib and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can cause neutropenia, and trastuzumab combined with myelosuppressive therapy increases the incidence of neutropenia and febrile neutropenia. The combination is used in HER2-positive breast cancer but requires hematologic surveillance.
What this interaction means in plain words
Palbociclib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palbociclib belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive myelosuppression: palbociclib inhibits CDK4/6 in marrow progenitors, and trastuzumab adds to neutropenia in combination regimens.
What to do
Check complete blood counts regularly, especially in the first cycles, and interrupt or reduce palbociclib for significant neutropenia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palbociclib
Other interactions of Trastuzumab
Frequently asked questions
Can I take Palbociclib with Trastuzumab?
MediHelp rates the interaction as moderate. Palbociclib and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can cause neutropenia, and trastuzumab combined with myelosuppressive therapy increases the incidence of neutropenia and febrile neutropenia. The combination is used in HER2-positive breast cancer but requires hematologic surveillance.
How serious is the interaction between Palbociclib and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check complete blood counts regularly, especially in the first cycles, and interrupt or reduce palbociclib for significant neutropenia.
What other medicines interact with Palbociclib?
MediHelp also lists interactions of Palbociclib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Palbociclib page.
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