Drug interactions
Palifermin + Temozolomide
Severity: Moderate
Palifermin and Temozolomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell proliferation, which may make rapidly dividing mucosal cells more vulnerable to cytotoxic chemotherapy. When given close to chemotherapy, it worsened the severity and duration of oral mucositis in trials of other agents. Data with temozolomide specifically are lacking.
What this interaction means in plain words
Palifermin and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palifermin belongs to Miscellaneous; Temozolomide belongs to Oncology.
Why it happens
Palifermin-induced epithelial proliferation increases sensitivity of mucosal cells to cytotoxic agents.
What to do
Do not give palifermin within 24 hours before, during, or within 24 hours after chemotherapy. Monitor for mucositis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temozolomide
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Temozolomide?
MediHelp rates the interaction as moderate. Palifermin and Temozolomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin stimulates epithelial cell proliferation, which may make rapidly dividing mucosal cells more vulnerable to cytotoxic chemotherapy. When given close to chemotherapy, it worsened the severity and duration of oral mucositis in trials of other agents. Data with temozolomide specifically are lacking.
How serious is the interaction between Palifermin and Temozolomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during, or within 24 hours after chemotherapy. Monitor for mucositis.
What other medicines interact with Temozolomide?
MediHelp also lists interactions of Temozolomide with, for example, Adenovirus types 4 and 7 live, Belatacept, Deferiprone. The full list is on the Temozolomide page.
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