Drug interactions
Palifermin + Temsirolimus
Severity: Moderate
Palifermin and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin given close to cytotoxic therapy may worsen the severity and duration of oral mucositis because it stimulates epithelial cell proliferation. Temsirolimus commonly causes stomatitis, but this interaction has not been shown specifically with temsirolimus.
What this interaction means in plain words
Palifermin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Palifermin belongs to Miscellaneous; Temsirolimus belongs to Oncology.
Why it happens
Palifermin-driven epithelial proliferation may increase sensitivity of mucosal cells to antiproliferative agents; specific mechanism with temsirolimus is not established.
What to do
Avoid giving palifermin within 24 hours before, during or after antineoplastic therapy per its labeling, and monitor for mucositis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Palifermin and Temsirolimus, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Other interactions of Palifermin
Frequently asked questions
Can I take Palifermin with Temsirolimus?
MediHelp rates the interaction as moderate. Palifermin and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Palifermin given close to cytotoxic therapy may worsen the severity and duration of oral mucositis because it stimulates epithelial cell proliferation. Temsirolimus commonly causes stomatitis, but this interaction has not been shown specifically with temsirolimus.
How serious is the interaction between Palifermin and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving palifermin within 24 hours before, during or after antineoplastic therapy per its labeling, and monitor for mucositis.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
