Drug interactions
Paliperidone + Procarbazine
Severity: Moderate
Paliperidone and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has monoamine oxidase inhibiting activity and can contribute to serotonergic toxicity, and it also causes sedation. Combination with an antipsychotic may increase CNS depression and rarely serotonin syndrome or neuroleptic malignant syndrome features.
What this interaction means in plain words
Paliperidone and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Procarbazine belongs to Oncology.
Why it happens
MAO inhibition may add to serotonergic and CNS depressant effects; the exact mechanism with paliperidone is not well established.
What to do
Monitor for hyperthermia, rigidity, autonomic instability, agitation and excessive sedation. Stop treatment and give supportive care if toxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Paliperidone with Procarbazine?
MediHelp rates the interaction as moderate. Paliperidone and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has monoamine oxidase inhibiting activity and can contribute to serotonergic toxicity, and it also causes sedation. Combination with an antipsychotic may increase CNS depression and rarely serotonin syndrome or neuroleptic malignant syndrome features.
How serious is the interaction between Paliperidone and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, autonomic instability, agitation and excessive sedation. Stop treatment and give supportive care if toxicity develops.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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