Drug interactions
Paliperidone + Sertraline
Severity: Moderate
Paliperidone and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can prolong the QT interval modestly, and sertraline may add a small effect. The combination is commonly used, but arrhythmia risk is higher with bradycardia, electrolyte abnormalities or cardiac disease.
What this interaction means in plain words
Paliperidone and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Sertraline belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Check ECG and electrolytes at baseline in patients with cardiac risk factors. Avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Frequently asked questions
Can I take Paliperidone with Sertraline?
MediHelp rates the interaction as moderate. Paliperidone and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can prolong the QT interval modestly, and sertraline may add a small effect. The combination is commonly used, but arrhythmia risk is higher with bradycardia, electrolyte abnormalities or cardiac disease.
How serious is the interaction between Paliperidone and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes at baseline in patients with cardiac risk factors. Avoid adding other QT-prolonging drugs.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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