Drug interactions
Paliperidone + Sufentanil
Severity: Major
Paliperidone and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a potent opioid, and combining it with paliperidone produces additive sedation and may cause respiratory depression and hypotension. The risk is highest around anesthesia or with higher opioid doses.
What this interaction means in plain words
Paliperidone and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Paliperidone belongs to Central Nervous System; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, plus additive hypotensive effects.
What to do
Titrate sufentanil to effect with reduced doses and monitor respiratory rate, oxygen saturation, sedation and blood pressure.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Paliperidone with Sufentanil?
MediHelp rates the interaction as major. Paliperidone and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is a potent opioid, and combining it with paliperidone produces additive sedation and may cause respiratory depression and hypotension. The risk is highest around anesthesia or with higher opioid doses.
How serious is the interaction between Paliperidone and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate sufentanil to effect with reduced doses and monitor respiratory rate, oxygen saturation, sedation and blood pressure.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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