Drug interactions
Paliperidone + Tetrabenazine
Severity: Major
Paliperidone and Tetrabenazine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so the combination raises the risk of torsades de pointes and other ventricular arrhythmias. Tetrabenazine also has additive extrapyramidal and sedative effects with antipsychotics.
What this interaction means in plain words
Paliperidone and Tetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Paliperidone belongs to Central Nervous System; Tetrabenazine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through pharmacodynamic effects; additive dopamine-related adverse effects.
What to do
Avoid if possible; otherwise obtain a baseline ECG, monitor QTc, and correct potassium and magnesium. Watch for parkinsonism, sedation and depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Tetrabenazine
- Dronedarone + Tetrabenazine Contraindicated
- Isocarboxazid + Tetrabenazine Contraindicated
- Linezolid + Tetrabenazine Contraindicated
- Phenelzine + Tetrabenazine Contraindicated
- Pimozide + Tetrabenazine Contraindicated
- Procarbazine + Tetrabenazine Contraindicated
Frequently asked questions
Can I take Paliperidone with Tetrabenazine?
MediHelp rates the interaction as major. Paliperidone and Tetrabenazine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QTc interval, so the combination raises the risk of torsades de pointes and other ventricular arrhythmias. Tetrabenazine also has additive extrapyramidal and sedative effects with antipsychotics.
How serious is the interaction between Paliperidone and Tetrabenazine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise obtain a baseline ECG, monitor QTc, and correct potassium and magnesium. Watch for parkinsonism, sedation and depression.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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