Drug interactions
Paliperidone + Tolazamide
Severity: Moderate
Paliperidone and Tolazamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paliperidone can raise blood glucose and may worsen diabetes control. This can reduce the effectiveness of tolazamide and require a higher sulfonylurea dose.
What this interaction means in plain words
Paliperidone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paliperidone belongs to Central Nervous System; Tolazamide belongs to Endocrine.
Why it happens
Atypical antipsychotics may cause insulin resistance and impaired insulin secretion, opposing the hypoglycemic action of sulfonylureas.
What to do
Monitor fasting glucose and HbA1c when starting or changing paliperidone, and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paliperidone
- Ibutilide + Paliperidone Contraindicated
- Paliperidone + Pimozide Contraindicated
- Paliperidone + Vandetanib Contraindicated
- Adagrasib + Paliperidone Major
- Amiodarone + Paliperidone Major
- Amisulpride + Paliperidone Major
Other interactions of Tolazamide
- Disopyramide + Tolazamide Major
- Insulin degludec-liraglutide + Tolazamide Major
- Aceclofenac + Tolazamide Moderate
- Acemetacin + Tolazamide Moderate
- Acetylsalicylic acid + Tolazamide Moderate
- Albiglutide + Tolazamide Moderate
Frequently asked questions
Can I take Paliperidone with Tolazamide?
MediHelp rates the interaction as moderate. Paliperidone and Tolazamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paliperidone can raise blood glucose and may worsen diabetes control. This can reduce the effectiveness of tolazamide and require a higher sulfonylurea dose.
How serious is the interaction between Paliperidone and Tolazamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c when starting or changing paliperidone, and adjust antidiabetic therapy as needed.
What other medicines interact with Paliperidone?
MediHelp also lists interactions of Paliperidone with, for example, Ibutilide, Pimozide, Vandetanib. The full list is on the Paliperidone page.
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